Дата: Воскресенье, 26.06.2016, 13:38:34 | Сообщение # 2
Группа: Гости
Docetaxel (as generic or tipsy the job high regard Taxotere) is a clinically well-established anti-mitotic chemotherapy medication (medication which interferes with cubicle department). It is acclimated to mostly payment the treatment of breast, ovarian, prostate, and non-small apartment lung cancer.[1 - [2 - [3 - Docetaxel has an FDA approved call for as a service to treatment of patients who have locally advanced, or metastatic heart of hearts or non small-cell lung cancer who partake of undergone anthracycline-based chemotherapy and failed to stop cancer chain or relapsed[4 - and a European subscribe to instead of work in hormone-refractory prostate cancer.[5 - According to a 2005 article in the quarterly Drugs, docetaxel administered as a one-hour infusion every three weeks commonly over a ten rotate despatch, docetaxel is considered as or more compelling than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.[1 - No matter what the effectiveness of docetaxel versus paclitaxel and other taxanes is undisturbed controversial. Individual more recent articles be suffering with build "no confirmation that regimens containing docetaxel raise the white flag greater benefits than those including paclitaxel."[6 - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week distribution schedule hardened to be and is until now considered compelling but new studies are indicating a weekly schedule effect be better. A 2010 article in On the qui vive Clinical Pharmacology states, "weekly charge has emerged as the optimal schedule." Docetaxel is marketed worldwide directed the name Taxotere on Sanofi-Aventis.[7 - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The evident expired in 2010.[citation Properties Docetaxel is of the chemotherapy opiate type; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an distillate from the bark of the rare Pacific yew tree Taxus brevifolia.[2 - Owed to scarcity of paclitaxel, far-flung delving was carried absent from primary to the formulation of docetaxel – an esterified yield of 10-deacetyl baccatin III, which is extracted from the renewable and gladly available European yew tree. Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl essential crowd on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side chain in place of of the benzyl amide in paclitaxel. The carbon 10 practical organize change causes docetaxel to be more sea water soluble than paclitaxel.[2 - Formulations and compositions Docetaxel is a white right and is the active ingredient convenient in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.[2 - [8 - The solution is a readable brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.[8 - 20 mg Taxotere is distributed in a blister carton containing one single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL sterile pyrogen-free anhydrous polysorbate 80, and a singular dosage Taxotere reliable vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion evening bag containing 0.9% sodium chloride or 5% glucose in the interest administration.[8 - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and profitable vials are combined to provide a unravelling of 10 mg/mL and the required dose is tense from this solution. Vials suffer with an overfill to compensate as a replacement for flowing harm during preparation, foaming, adhesion to vial walls and the dead volume. 20 mg vials may be stored for 24 months under 25 °C away from understanding and 80 mg vials respecting 26 months in the anyhow conditions.[8 - Recently Sanofi has got okay because of one-vial formulation.[citation needed - With this one-vial formulation, the preparation of the infusion infusion is simplified by eliminating the blue ribbon dilution step. The two-vial and one-vial formulations in the at any rate drug substance, docetaxel trihydrate, and the uniform excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous solution that contains the unchanging psychedelic nub in the after all is said concentration as the already approved two-vial formulation. The unmodified form, standing, and measure of polysorbate 80 are present in the infusion solution of both formulations. The solely unlikeness between these two formulations is the measure of ethanol. From http://www.tcsindustry.com - TCS INDUSTRY LTD
